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BDBM50462762 CHEMBL4246041

SMILES: Cn1nc(c2ccc(Nc3n[nH]c4cccnc34)cc12)C(F)(F)F

InChI Key: InChIKey=APKCIUSODJJQDP-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50462762   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462762
PNG
(CHEMBL4246041)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4cccnc34)cc12)C(F)(F)F
Show InChI InChI=1S/C15H11F3N6/c1-24-11-7-8(4-5-9(11)13(23-24)15(16,17)18)20-14-12-10(21-22-14)3-2-6-19-12/h2-7H,1H3,(H2,20,21,22)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 119n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair