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BDBM50462765 CHEMBL4251433

SMILES: Cn1nc(c2ccc(Nc3n[nH]c4ncccc34)cc12)C1(C)CC1

InChI Key: InChIKey=XDITXAVXUYECFF-UHFFFAOYSA-N

Data: 1 EC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50462765   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462765
PNG
(CHEMBL4251433)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4ncccc34)cc12)C1(C)CC1
Show InChI InChI=1S/C18H18N6/c1-18(7-8-18)15-12-6-5-11(10-14(12)24(2)23-15)20-17-13-4-3-9-19-16(13)21-22-17/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21,22)
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 129n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair