BDBM50462775 CHEMBL4248273::US10508105, Compound 20

SMILES: Cn1nc(OC2CCOCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12

InChI Key: InChIKey=HZAPEUKZUCPGNJ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50462775   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462775 (CHEMBL4248273 | US10508105, Compound 20) Show SMILES Cn1nc(OC2CCOCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C19H20N6O2/c1-25-16-11-12(21-18-17-15(22-23-18)3-2-8-20-17)4-5-14(16)19(24-25)27-13-6-9-26-10-7-13/h2-5,8,11,13H,6-7,9-10H2,1H3,(H2,21,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	45.4	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiatior of metabotropic glutamate receptor activity, in ...				US Patent US10508105 (2019) BindingDB Entry DOI: 10.7270/Q2WH2SC2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462775 (CHEMBL4248273 | US10508105, Compound 20) Show SMILES Cn1nc(OC2CCOCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C19H20N6O2/c1-25-16-11-12(21-18-17-15(22-23-18)3-2-8-20-17)4-5-14(16)19(24-25)27-13-6-9-26-10-7-13/h2-5,8,11,13H,6-7,9-10H2,1H3,(H2,21,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair