BDBM50463143 CHEMBL4245127

SMILES: CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI Key: InChIKey=MEBPGJFXXVRICE-OMAOVEBHSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50463143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin B (Homo sapiens (Human))	BDBM50463143 (CHEMBL4245127) Show SMILES CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C29H36N2O6/c1-4-36-27(33)18-17-26(32)24(16-15-22-11-7-5-8-12-22)30-28(34)25(19-21(2)3)31-29(35)37-20-23-13-9-6-10-14-23/h5-14,17-18,21,24-25H,4,15-16,19-20H2,1-3H3,(H,30,34)(H,31,35)/b18-17+/t24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of human cathepsin B using Cbz-Phe-Arg-AMC as substrate				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Cysteine protease falcipain-2 (Plasmodium falciparum)	BDBM50463143 (CHEMBL4245127) Show SMILES CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C29H36N2O6/c1-4-36-27(33)18-17-26(32)24(16-15-22-11-7-5-8-12-22)30-28(34)25(19-21(2)3)31-29(35)37-20-23-13-9-6-10-14-23/h5-14,17-18,21,24-25H,4,15-16,19-20H2,1-3H3,(H,30,34)(H,31,35)/b18-17+/t24-,25-/m0/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain-2 using Cbz-Phe-Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50463143 (CHEMBL4245127) Show SMILES CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C29H36N2O6/c1-4-36-27(33)18-17-26(32)24(16-15-22-11-7-5-8-12-22)30-28(34)25(19-21(2)3)31-29(35)37-20-23-13-9-6-10-14-23/h5-14,17-18,21,24-25H,4,15-16,19-20H2,1-3H3,(H,30,34)(H,31,35)/b18-17+/t24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50463143 (CHEMBL4245127) Show SMILES CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C29H36N2O6/c1-4-36-27(33)18-17-26(32)24(16-15-22-11-7-5-8-12-22)30-28(34)25(19-21(2)3)31-29(35)37-20-23-13-9-6-10-14-23/h5-14,17-18,21,24-25H,4,15-16,19-20H2,1-3H3,(H,30,34)(H,31,35)/b18-17+/t24-,25-/m0/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi cruzain				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Rhodesain (Trypanosoma brucei rhodesiense)	BDBM50463143 (CHEMBL4245127) Show SMILES CCOC(=O)\C=C\C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C29H36N2O6/c1-4-36-27(33)18-17-26(32)24(16-15-22-11-7-5-8-12-22)30-28(34)25(19-21(2)3)31-29(35)37-20-23-13-9-6-10-14-23/h5-14,17-18,21,24-25H,4,15-16,19-20H2,1-3H3,(H,30,34)(H,31,35)/b18-17+/t24-,25-/m0/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence method				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair