BindingDB logo
myBDB logout

BDBM50463632 CHEMBL4250191

SMILES: COc1ccc(cc1)N(C)c1ncnc2occ(C)c12

InChI Key: InChIKey=UVZUIESPIIIPQW-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50463632   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50463632
PNG
(CHEMBL4250191)
Show SMILES COc1ccc(cc1)N(C)c1ncnc2occ(C)c12
Show InChI InChI=1S/C15H15N3O2/c1-10-8-20-15-13(10)14(16-9-17-15)18(2)11-4-6-12(19-3)7-5-11/h4-9H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB-induced PDGFRbeta activation in human SH-SY5Y cells pretreated for 60 mins followed by PDGF-BB addition and measured after 10 m...


Bioorg Med Chem Lett 28: 3085-3093 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.039
BindingDB Entry DOI: 10.7270/Q24X5BF1
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50463632
PNG
(CHEMBL4250191)
Show SMILES COc1ccc(cc1)N(C)c1ncnc2occ(C)c12
Show InChI InChI=1S/C15H15N3O2/c1-10-8-20-15-13(10)14(16-9-17-15)18(2)11-4-6-12(19-3)7-5-11/h4-9H,1-3H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of tubulin assembly in bovine brain homogenate assessed as reduction in turbidity increase preincubated for 15 mins followed by GTP additi...


J Med Chem 59: 5752-65 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00237
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50463632
PNG
(CHEMBL4250191)
Show SMILES COc1ccc(cc1)N(C)c1ncnc2occ(C)c12
Show InChI InChI=1S/C15H15N3O2/c1-10-8-20-15-13(10)14(16-9-17-15)18(2)11-4-6-12(19-3)7-5-11/h4-9H,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of EGF-induced EGFR activation in human A431 cells pretreated for 60 mins followed by EGF addition and measured after 10 mins by ELISA


Bioorg Med Chem Lett 28: 3085-3093 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.039
BindingDB Entry DOI: 10.7270/Q24X5BF1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50463632
PNG
(CHEMBL4250191)
Show SMILES COc1ccc(cc1)N(C)c1ncnc2occ(C)c12
Show InChI InChI=1S/C15H15N3O2/c1-10-8-20-15-13(10)14(16-9-17-15)18(2)11-4-6-12(19-3)7-5-11/h4-9H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.30n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISA


Bioorg Med Chem Lett 28: 3085-3093 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.039
BindingDB Entry DOI: 10.7270/Q24X5BF1
More data for this
Ligand-Target Pair