BDBM50463632 CHEMBL4250191
SMILES: COc1ccc(cc1)N(C)c1ncnc2occ(C)c12
InChI Key: InChIKey=UVZUIESPIIIPQW-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50463632![]() (CHEMBL4250191) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of PDGF-BB-induced PDGFRbeta activation in human SH-SY5Y cells pretreated for 60 mins followed by PDGF-BB addition and measured after 10 m... | Bioorg Med Chem Lett 28: 3085-3093 (2018) Article DOI: 10.1016/j.bmcl.2018.07.039 BindingDB Entry DOI: 10.7270/Q24X5BF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50463632![]() (CHEMBL4250191) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of tubulin assembly in bovine brain homogenate assessed as reduction in turbidity increase preincubated for 15 mins followed by GTP additi... | J Med Chem 59: 5752-65 (2016) Article DOI: 10.1021/acs.jmedchem.6b00237 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50463632![]() (CHEMBL4250191) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of EGF-induced EGFR activation in human A431 cells pretreated for 60 mins followed by EGF addition and measured after 10 mins by ELISA | Bioorg Med Chem Lett 28: 3085-3093 (2018) Article DOI: 10.1016/j.bmcl.2018.07.039 BindingDB Entry DOI: 10.7270/Q24X5BF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50463632![]() (CHEMBL4250191) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISA | Bioorg Med Chem Lett 28: 3085-3093 (2018) Article DOI: 10.1016/j.bmcl.2018.07.039 BindingDB Entry DOI: 10.7270/Q24X5BF1 | |||||||||||
More data for this Ligand-Target Pair |