BDBM50463855 CHEMBL4248077

SMILES: Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=IJTSMWHYNKDXNG-INIZCTEOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50463855   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50463855 (CHEMBL4248077) Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50463855 (CHEMBL4248077) Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50463855 (CHEMBL4248077) Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair