BDBM50465617 CHEMBL4280979

SMILES: OC(=O)c1ccc(CN2CCc3c([nH]c4ccccc34)C2c2ccccc2)cc1

InChI Key: InChIKey=WCCPZEOFGDGTBI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50465617   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50465617 (CHEMBL4280979) Show SMILES OC(=O)c1ccc(CN2CCc3c([nH]c4ccccc34)C2c2ccccc2)cc1 Show InChI InChI=1S/C25H22N2O2/c28-25(29)19-12-10-17(11-13-19)16-27-15-14-21-20-8-4-5-9-22(20)26-23(21)24(27)18-6-2-1-3-7-18/h1-13,24,26H,14-16H2,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...				J Med Chem 61: 6140-6152 (2018) Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3
					More data for this Ligand-Target Pair