BDBM50465618 CHEMBL4291622

SMILES: O=C(CN1CCc2c([nH]c3ccccc23)C1c1ccccc1)c1ccccc1

InChI Key: InChIKey=OLZYWVFADQKAQN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50465618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50465618 (CHEMBL4291622) Show SMILES O=C(CN1CCc2c([nH]c3ccccc23)C1c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H22N2O/c28-23(18-9-3-1-4-10-18)17-27-16-15-21-20-13-7-8-14-22(20)26-24(21)25(27)19-11-5-2-6-12-19/h1-14,25-26H,15-17H2	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...				J Med Chem 61: 6140-6152 (2018) Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3
					More data for this Ligand-Target Pair