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BDBM50467282 CHEMBL4290086

SMILES: COc1ccccc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C

InChI Key: InChIKey=LORLESVGPXXLDO-SANMLTNESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50467282   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MDM2-MDMX


(Homo sapiens (Human))		BDBM50467282
PNG
(CHEMBL4290086)
Show SMILES COc1ccccc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C29H27Cl2N3O2/c1-16(2)33-27-25(32-28(33)22-8-6-7-9-24(22)36-5)29(35)34(23-15-20(31)11-10-17(23)3)26(27)21-13-12-19(30)14-18(21)4/h6-16,26H,1-5H3/t26-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0740n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of Cy5-labeled p53 derived TFSDLWKLL peptide binding to C-terminal biotin-labelled human MDM2 (2 to 188 residues) by TR-FRET assay

Bioorg Med Chem Lett 28: 3404-3408 (2018)


Article DOI: 10.1016/j.bmcl.2018.08.027
BindingDB Entry DOI: 10.7270/Q2C82D0H
More data for this
Ligand-Target Pair