BDBM50467400 CHEMBL4281785

SMILES: Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1

InChI Key: InChIKey=VICOBHISBRNOJO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50467400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50467400 (CHEMBL4281785) Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C29H36N6O4/c1-21-20-30-29(32-24-12-14-25(15-13-24)35-16-18-39-19-17-35)33-28(21)22-8-10-23(11-9-22)31-26(36)6-4-2-3-5-7-27(37)34-38/h8-15,20,38H,2-7,16-19H2,1H3,(H,31,36)(H,34,37)(H,30,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...				Eur J Med Chem 158: 593-619 (2018) Article DOI: 10.1016/j.ejmech.2018.09.024 BindingDB Entry DOI: 10.7270/Q2Z3229Z
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50467400 (CHEMBL4281785) Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C29H36N6O4/c1-21-20-30-29(32-24-12-14-25(15-13-24)35-16-18-39-19-17-35)33-28(21)22-8-10-23(11-9-22)31-26(36)6-4-2-3-5-7-27(37)34-38/h8-15,20,38H,2-7,16-19H2,1H3,(H,31,36)(H,34,37)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...				Eur J Med Chem 158: 593-619 (2018) Article DOI: 10.1016/j.ejmech.2018.09.024 BindingDB Entry DOI: 10.7270/Q2Z3229Z
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50467400 (CHEMBL4281785) Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 Show InChI InChI=1S/C29H36N6O4/c1-21-20-30-29(32-24-12-14-25(15-13-24)35-16-18-39-19-17-35)33-28(21)22-8-10-23(11-9-22)31-26(36)6-4-2-3-5-7-27(37)34-38/h8-15,20,38H,2-7,16-19H2,1H3,(H,31,36)(H,34,37)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...				Eur J Med Chem 158: 593-619 (2018) Article DOI: 10.1016/j.ejmech.2018.09.024 BindingDB Entry DOI: 10.7270/Q2Z3229Z
					More data for this Ligand-Target Pair