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SMILES: Clc1nc2c(nc(nc2nc1NCc1ccccc1)N1CCNCC1)N1CCCC1

InChI Key: InChIKey=GEJPLNWGEJLXJN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50471928   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50471928
PNG
(CHEMBL141487)
Show SMILES Clc1nc2c(nc(nc2nc1NCc1ccccc1)N1CCNCC1)N1CCCC1
Show InChI InChI=1S/C21H25ClN8/c22-17-19(24-14-15-6-2-1-3-7-15)26-18-16(25-17)20(29-10-4-5-11-29)28-21(27-18)30-12-8-23-9-13-30/h1-3,6-7,23H,4-5,8-14H2,(H,24,26,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



University of Kaiserslautern

Curated by ChEMBL


Assay Description
Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...

J Med Chem 41: 4733-43 (1998)


Article DOI: 10.1021/jm981021v
BindingDB Entry DOI: 10.7270/Q2SN0CQ8
More data for this
Ligand-Target Pair