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SMILES: CN(C)c1nc(nc2nc(NCc3ccccc3)c(Cl)nc12)N1CCNCC1

InChI Key: InChIKey=KNPLFFHAIBJZBG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50471930   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50471930
PNG
(CHEMBL142504)
Show SMILES CN(C)c1nc(nc2nc(NCc3ccccc3)c(Cl)nc12)N1CCNCC1
Show InChI InChI=1S/C19H23ClN8/c1-27(2)18-14-16(25-19(26-18)28-10-8-21-9-11-28)24-17(15(20)23-14)22-12-13-6-4-3-5-7-13/h3-7,21H,8-12H2,1-2H3,(H,22,24,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Kaiserslautern

Curated by ChEMBL


Assay Description
Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...

J Med Chem 41: 4733-43 (1998)


Article DOI: 10.1021/jm981021v
BindingDB Entry DOI: 10.7270/Q2SN0CQ8
More data for this
Ligand-Target Pair