Found 3 hits for monomerid = 50473084 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473084
(CHEMBL434516)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50473084
(CHEMBL434516)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aorta |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50473084
(CHEMBL434516)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this Ligand-Target Pair | |