BDBM50474163 CHEMBL64544

SMILES: COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12

InChI Key: InChIKey=KSDNSDVILMJIKK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50474163   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50474163 (CHEMBL64544) Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:40,t:11| Show InChI InChI=1S/C31H33N5O5/c1-40-26-16-12-21(19-27(26)41-2)30-23-7-3-4-8-24(23)31(39)36(35-30)18-6-5-9-28(37)32-22-13-10-20(11-14-22)25-15-17-29(38)34-33-25/h3-4,10-17,19,23-24H,5-9,18H2,1-2H3,(H,32,37)(H,34,38)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils				J Med Chem 46: 2008-16 (2003) Article DOI: 10.1021/jm030776l BindingDB Entry DOI: 10.7270/Q2S1857B
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase A/B (Homo sapiens (Human))	BDBM50474163 (CHEMBL64544) Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:40,t:11| Show InChI InChI=1S/C31H33N5O5/c1-40-26-16-12-21(19-27(26)41-2)30-23-7-3-4-8-24(23)31(39)36(35-30)18-6-5-9-28(37)32-22-13-10-20(11-14-22)25-15-17-29(38)34-33-25/h3-4,10-17,19,23-24H,5-9,18H2,1-2H3,(H,32,37)(H,34,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets.				J Med Chem 46: 2008-16 (2003) Article DOI: 10.1021/jm030776l BindingDB Entry DOI: 10.7270/Q2S1857B
					More data for this Ligand-Target Pair