BDBM50474812 CHEMBL93282

SMILES: C[C@H](Nc1nccc(n1)-c1c(-c2ccc(F)cc2)c(=O)n2CCCCn12)c1ccccc1

InChI Key: InChIKey=GZPYMRRCHNCWPW-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50474812   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 11/12/13/14 (Homo sapiens (Human))	BDBM50474812 (CHEMBL93282) Show SMILES C[C@H](Nc1nccc(n1)-c1c(-c2ccc(F)cc2)c(=O)n2CCCCn12)c1ccccc1 Show InChI InChI=1S/C25H24FN5O/c1-17(18-7-3-2-4-8-18)28-25-27-14-13-21(29-25)23-22(19-9-11-20(26)12-10-19)24(32)31-16-6-5-15-30(23)31/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,27,28,29)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)				J Med Chem 47: 2724-7 (2004) Article DOI: 10.1021/jm049968m BindingDB Entry DOI: 10.7270/Q2ZC85NQ
					More data for this Ligand-Target Pair