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SMILES: CC(C1CCCCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=SUYIHEGPYVNQBO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50476924   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50476924
PNG
(CHEMBL393316)
Show SMILES CC(C1CCCCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25Cl2NO3S/c1-15(16-5-3-2-4-6-16)24(21-13-19(23)8-7-17(21)14-25)28(26,27)20-11-9-18(22)10-12-20/h7-13,15-16,25H,2-6,14H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA

Bioorg Med Chem Lett 17: 4432-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465
More data for this
Ligand-Target Pair