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SMILES: C[C@H](NC(=O)Cc1cccnc1)C(=O)NC1c2ccccc2C=NN(C)C1=O

InChI Key: InChIKey=VAYYYCIYWDRNOL-FVRDMJKUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50477515   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50477515
PNG
(CHEMBL246371)
Show SMILES C[C@H](NC(=O)Cc1cccnc1)C(=O)NC1c2ccccc2C=NN(C)C1=O |c:24|
Show InChI InChI=1S/C20H21N5O3/c1-13(23-17(26)10-14-6-5-9-21-11-14)19(27)24-18-16-8-4-3-7-15(16)12-22-25(2)20(18)28/h3-9,11-13,18H,10H2,1-2H3,(H,23,26)(H,24,27)/t13-,18?/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 162n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cells

Bioorg Med Chem Lett 17: 4006-11 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.082
BindingDB Entry DOI: 10.7270/Q2XD14GF
More data for this
Ligand-Target Pair