BDBM50480063 CHEMBL511928

SMILES: [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1ncn(n1)-c1ccc(F)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1

InChI Key: InChIKey=CKIKDJDGOCOXEI-YCRNBWNJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50480063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50480063 (CHEMBL511928) Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1ncn(n1)-c1ccc(F)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r| Show InChI InChI=1S/C24H23F4N5O2S/c25-20-5-7-21(8-6-20)33-14-29-22(30-33)16-2-1-15-10-18-3-4-19(11-17(15)9-16)23(18)12-32(13-24(26,27)28)36(34,35)31-23/h1-2,5-9,14,18-19,31H,3-4,10-13H2/t18-,19+,23+/m0/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay				J Med Chem 52: 3441-4 (2009) Article DOI: 10.1021/jm900056p BindingDB Entry DOI: 10.7270/Q2B85BZ2
					More data for this Ligand-Target Pair