null
SMILES: CCOC(=O)c1cc(nn1Cc1ccccc1)-c1sc(NC(=O)C(C)(C)C)nc1C
InChI Key: InChIKey=YGBBVYDQOPWHSA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50482134 (CHEMBL1099214) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Binding affinity to human CFTR F508 deletion mutant expressed in FRT cells assessed as increase in iodine influx after 16 to 20 hrs by fluorescence a... | J Med Chem 53: 3772-81 (2010) Article DOI: 10.1021/jm100235h BindingDB Entry DOI: 10.7270/Q2VD728K | |||||||||||
More data for this Ligand-Target Pair |