null

SMILES: CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)C(=O)OC

InChI Key: InChIKey=INPIJMMJIYSUTN-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50483754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50483754 (CHEMBL1770759) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)C(=O)OC |r| Show InChI InChI=1S/C21H26F2N4O4/c1-5-6-16(25-18(28)9-13-7-14(22)10-15(23)8-13)19(29)26-17-11-27(12-24-17)21(2,3)20(30)31-4/h7-8,10-12,16H,5-6,9H2,1-4H3,(H,25,28)(H,26,29)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...				Bioorg Med Chem Lett 21: 2631-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.117 BindingDB Entry DOI: 10.7270/Q2K64MX1
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50483754 (CHEMBL1770759) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)C(=O)OC |r| Show InChI InChI=1S/C21H26F2N4O4/c1-5-6-16(25-18(28)9-13-7-14(22)10-15(23)8-13)19(29)26-17-11-27(12-24-17)21(2,3)20(30)31-4/h7-8,10-12,16H,5-6,9H2,1-4H3,(H,25,28)(H,26,29)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassay				Bioorg Med Chem Lett 21: 2631-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.117 BindingDB Entry DOI: 10.7270/Q2K64MX1
					More data for this Ligand-Target Pair