null

SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2ccc(N)nc2)c1F

InChI Key: InChIKey=CDDYERXWVMMNOR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50484700   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484700 (CHEMBL1945019) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2ccc(N)nc2)c1F Show InChI InChI=1S/C15H16F2N4O3S/c1-2-7-25(23,24)21-11-5-4-10(16)13(14(11)17)15(22)20-9-3-6-12(18)19-8-9/h3-6,8,21H,2,7H2,1H3,(H2,18,19)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human A375 cells after 1 hr by fluorescence analysis				ACS Med Chem Lett 2: 342-7 (2011) Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484700 (CHEMBL1945019) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2ccc(N)nc2)c1F Show InChI InChI=1S/C15H16F2N4O3S/c1-2-7-25(23,24)21-11-5-4-10(16)13(14(11)17)15(22)20-9-3-6-12(18)19-8-9/h3-6,8,21H,2,7H2,1H3,(H2,18,19)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length human B-Raf V600E mutant expressed in baculovirus infected insect cells assessed as [gamma-33P]incorporation into MEK after...				ACS Med Chem Lett 2: 342-7 (2011) Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484700 (CHEMBL1945019) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2ccc(N)nc2)c1F Show InChI InChI=1S/C15H16F2N4O3S/c1-2-7-25(23,24)21-11-5-4-10(16)13(14(11)17)15(22)20-9-3-6-12(18)19-8-9/h3-6,8,21H,2,7H2,1H3,(H2,18,19)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human MALME-3M cells after 1 hr by fluorescence analysis				ACS Med Chem Lett 2: 342-7 (2011) Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM
					More data for this Ligand-Target Pair