BDBM50485447 CHEMBL2059819
SMILES: NC(=O)[C@@H](CCC(F)(F)F)N(C[C@H]1C[C@@H]1C#N)S(=O)(=O)c1ccc(Cl)cc1
InChI Key: InChIKey=PPBDKFUHZARRNW-JTNHKYCSSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Presenilin-1 (Homo sapiens (Human)) | BDBM50485447 (CHEMBL2059819) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutant | J Med Chem 55: 3414-24 (2012) Article DOI: 10.1021/jm300094u BindingDB Entry DOI: 10.7270/Q23F4SHS | |||||||||||
More data for this Ligand-Target Pair |