BDBM50494267 CHEMBL3087476

SMILES: CC1(C)OC[C@H](COc2ccc3COc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)O1

InChI Key: InChIKey=GFKPZHKRBFHHHC-IBGZPJMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50494267   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50494267 (CHEMBL3087476) Show SMILES CC1(C)OC[C@H](COc2ccc3COc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)O1 |r| Show InChI InChI=1S/C26H23F2NO5/c1-26(2)33-14-19(34-26)13-31-18-6-3-15-12-32-24-10-17(5-7-20(24)25(30)21(15)11-18)29-23-8-4-16(27)9-22(23)28/h3-11,19,29H,12-14H2,1-2H3/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATP				J Med Chem 56: 8561-78 (2013) Article DOI: 10.1021/jm401276h BindingDB Entry DOI: 10.7270/Q2Q81H2C
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50494267 (CHEMBL3087476) Show SMILES CC1(C)OC[C@H](COc2ccc3COc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)O1 |r| Show InChI InChI=1S/C26H23F2NO5/c1-26(2)33-14-19(34-26)13-31-18-6-3-15-12-32-24-10-17(5-7-20(24)25(30)21(15)11-18)29-23-8-4-16(27)9-22(23)28/h3-11,19,29H,12-14H2,1-2H3/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISA				J Med Chem 56: 8561-78 (2013) Article DOI: 10.1021/jm401276h BindingDB Entry DOI: 10.7270/Q2Q81H2C
					More data for this Ligand-Target Pair