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SMILES: OC(=O)[C@H]1[C@@H](Cc2c[nH]c3ccccc23)CCN1C(=O)c1ccc2ccccc2c1

InChI Key: InChIKey=KJXIJMCTHOJNEM-WZONZLPQSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50495478   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))		BDBM50495478
PNG
(CHEMBL3109076)
Show SMILES OC(=O)[C@H]1[C@@H](Cc2c[nH]c3ccccc23)CCN1C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C25H22N2O3/c28-24(19-10-9-16-5-1-2-6-17(16)13-19)27-12-11-18(23(27)25(29)30)14-20-15-26-22-8-4-3-7-21(20)22/h1-10,13,15,18,23,26H,11-12,14H2,(H,29,30)/t18-,23-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Paris 6

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DNMT1 expressed in H19 cells assessed as inhibition of tritiated methyl incorporation from [3H]-labeled AdoMet into h...

J Med Chem 57: 421-34 (2014)


Article DOI: 10.1021/jm401419p
BindingDB Entry DOI: 10.7270/Q2QN69Q3
More data for this
Ligand-Target Pair