BDBM50495729 CHEMBL3113937
SMILES: [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccccc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
InChI Key: InChIKey=MQQMKMLATGRCEW-QFIPXVFZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50495729![]() (CHEMBL3113937) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0720 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A. Curated by ChEMBL | Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay | J Med Chem 57: 793-816 (2014) Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50495729![]() (CHEMBL3113937) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A. Curated by ChEMBL | Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA | J Med Chem 57: 793-816 (2014) Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D | |||||||||||
More data for this Ligand-Target Pair |