null

SMILES: OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=MRXFOJGYISURGY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50495776   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50495776 (CHEMBL3114924) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H18FN3O2S/c22-15-7-5-14(6-8-15)20-24-17-2-1-11-28-19(17)21(25-20)23-16-9-3-13(4-10-16)12-18(26)27/h3-10H,1-2,11-12H2,(H,26,27)(H,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495776 (CHEMBL3114924) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H18FN3O2S/c22-15-7-5-14(6-8-15)20-24-17-2-1-11-28-19(17)21(25-20)23-16-9-3-13(4-10-16)12-18(26)27/h3-10H,1-2,11-12H2,(H,26,27)(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair