null

SMILES: COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1

InChI Key: InChIKey=ONTYRRHLBFPVPK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50495777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495777 (CHEMBL3114948) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H19F2N3O5S/c1-32-18-7-5-13(9-16(18)24)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)15(23)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50495777 (CHEMBL3114948) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H19F2N3O5S/c1-32-18-7-5-13(9-16(18)24)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)15(23)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair