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BDBM50496326 CHEMBL1348295

SMILES: OC(COc1ccc(cc1)C#N)CN1CCN(CC1)C(c1ccccc1)c1ccccc1

InChI Key: InChIKey=PLIYSHLLWGTRBD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50496326   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Menin


(Homo sapiens (Human))		BDBM50496326
PNG
(CHEMBL1348295)
Show SMILES OC(COc1ccc(cc1)C#N)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N3O2/c28-19-22-11-13-26(14-12-22)32-21-25(31)20-29-15-17-30(18-16-29)27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,25,27,31H,15-18,20-21H2
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70E+4n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged menin-biotinylated MLL (4 to 15) interaction after 1 hr by HTRF assay

J Med Chem 57: 1543-56 (2014)


Article DOI: 10.1021/jm401868d
BindingDB Entry DOI: 10.7270/Q2XS5ZCB
More data for this
Ligand-Target Pair