Found 5 hits for monomerid = 50498053 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50498053
(CHEMBL3329545)Show SMILES CC1(C)CC1C(=O)N1CC2CC(C1)N2 |THB:5:7:10:13| Show InChI InChI=1S/C11H18N2O/c1-11(2)4-9(11)10(14)13-5-7-3-8(6-13)12-7/h7-9,12H,3-6H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H] nicotine from human alpha4beta2 nAChR transfected in SH-EP1 cells by liquid scintillation counting |
Eur J Med Chem 86: 60-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-2/beta-3
(Homo sapiens (Human)) | BDBM50498053
(CHEMBL3329545)Show SMILES CC1(C)CC1C(=O)N1CC2CC(C1)N2 |THB:5:7:10:13| Show InChI InChI=1S/C11H18N2O/c1-11(2)4-9(11)10(14)13-5-7-3-8(6-13)12-7/h7-9,12H,3-6H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation counting |
Eur J Med Chem 86: 60-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50498053
(CHEMBL3329545)Show SMILES CC1(C)CC1C(=O)N1CC2CC(C1)N2 |THB:5:7:10:13| Show InChI InChI=1S/C11H18N2O/c1-11(2)4-9(11)10(14)13-5-7-3-8(6-13)12-7/h7-9,12H,3-6H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human alpha4beta2 nAChR low sensitivity isoform transfected in SH-EP1 cells assessed as calcium flux by FLIPR assay |
Eur J Med Chem 86: 60-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-2/beta-3
(Homo sapiens (Human)) | BDBM50498053
(CHEMBL3329545)Show SMILES CC1(C)CC1C(=O)N1CC2CC(C1)N2 |THB:5:7:10:13| Show InChI InChI=1S/C11H18N2O/c1-11(2)4-9(11)10(14)13-5-7-3-8(6-13)12-7/h7-9,12H,3-6H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 540 | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assay |
Eur J Med Chem 86: 60-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50498053
(CHEMBL3329545)Show SMILES CC1(C)CC1C(=O)N1CC2CC(C1)N2 |THB:5:7:10:13| Show InChI InChI=1S/C11H18N2O/c1-11(2)4-9(11)10(14)13-5-7-3-8(6-13)12-7/h7-9,12H,3-6H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human alpha4beta2 nAChR transfected in SH-EP1 cells assessed as calcium flux by FLIPR assay |
Eur J Med Chem 86: 60-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H |
More data for this
Ligand-Target Pair | |
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