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SMILES: CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O

InChI Key: InChIKey=HGXLXQVWGBALSS-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50498787   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50498787
PNG
(CHEMBL3623718)
Show SMILES CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r|
Show InChI InChI=1S/C20H22N2O3S2/c1-26-13-11-14(20(24)25)21-19(23)10-12-22-15-6-2-4-8-17(15)27-18-9-5-3-7-16(18)22/h2-9,14H,10-13H2,1H3,(H,21,23)(H,24,25)/t14-/m0/s1
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n/an/a 1.17E+4n/an/an/an/an/an/a



Alexandru Ioan Cuza University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis

Bioorg Med Chem Lett 25: 4447-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS
More data for this
Ligand-Target Pair