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SMILES: CN1CCN(CC1)C(=O)c1cc(ccn1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1

InChI Key: InChIKey=QYTYBJUOTNVWBP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50499394   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM50499394
PNG
(CHEMBL3736509)
Show SMILES CN1CCN(CC1)C(=O)c1cc(ccn1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C25H30N10O2/c1-32-6-8-33(9-7-32)23(36)20-14-18(2-4-27-20)35-5-3-19-21(17-15-28-24(26)29-16-17)30-25(31-22(19)35)34-10-12-37-13-11-34/h2,4,14-16H,3,5-13H2,1H3,(H2,26,28,29)
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PC cid
PC sid
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Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assay

Bioorg Med Chem 23: 7650-60 (2015)


Article DOI: 10.1016/j.bmc.2015.11.009
BindingDB Entry DOI: 10.7270/Q2CN76XT
More data for this
Ligand-Target Pair