BDBM50500192 CHEMBL3746924

SMILES: CCS(=O)(=O)Nc1cncc(c1)-c1c(C#N)c2ccccc2n1C

InChI Key: InChIKey=IEOQZKGIYGRWJF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50500192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM50500192 (CHEMBL3746924) Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1c(C#N)c2ccccc2n1C Show InChI InChI=1S/C17H16N4O2S/c1-3-24(22,23)20-13-8-12(10-19-11-13)17-15(9-18)14-6-4-5-7-16(14)21(17)2/h4-8,10-11,20H,3H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIA				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair