null

SMILES: Fc1ccc(c(F)c1)-n1nc(OCCN2CCNC2=O)c2cc(F)ccc12

InChI Key: InChIKey=JGWFEASWZPTQCO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50500960 (CHEMBL3800304) Show SMILES Fc1ccc(c(F)c1)-n1nc(OCCN2CCNC2=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H15F3N4O2/c19-11-1-3-15-13(9-11)17(27-8-7-24-6-5-22-18(24)26)23-25(15)16-4-2-12(20)10-14(16)21/h1-4,9-10H,5-8H2,(H,22,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp method				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50500960 (CHEMBL3800304) Show SMILES Fc1ccc(c(F)c1)-n1nc(OCCN2CCNC2=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H15F3N4O2/c19-11-1-3-15-13(9-11)17(27-8-7-24-6-5-22-18(24)26)23-25(15)16-4-2-12(20)10-14(16)21/h1-4,9-10H,5-8H2,(H,22,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50500960 (CHEMBL3800304) Show SMILES Fc1ccc(c(F)c1)-n1nc(OCCN2CCNC2=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H15F3N4O2/c19-11-1-3-15-13(9-11)17(27-8-7-24-6-5-22-18(24)26)23-25(15)16-4-2-12(20)10-14(16)21/h1-4,9-10H,5-8H2,(H,22,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Curated by ChEMBL					Assay Description Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...				J Med Chem 59: 3373-91 (2016) Article DOI: 10.1021/acs.jmedchem.6b00063 BindingDB Entry DOI: 10.7270/Q2C250GW
					More data for this Ligand-Target Pair