BDBM50500971 CHEMBL3798983
SMILES: CNC(=O)c1cc(Oc2ccc3nc(NC(=O)Nc4ccc(Cl)c(Cl)c4)sc3c2)ccn1
InChI Key: InChIKey=KNOQVYGPDZKJHQ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50500971![]() (CHEMBL3798983) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KIST) Curated by ChEMBL | Assay Description Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation counting | Eur J Med Chem 115: 201-16 (2016) Article DOI: 10.1016/j.ejmech.2016.02.039 BindingDB Entry DOI: 10.7270/Q27947QQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50500971![]() (CHEMBL3798983) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KIST) Curated by ChEMBL | Assay Description Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assay | Eur J Med Chem 115: 201-16 (2016) Article DOI: 10.1016/j.ejmech.2016.02.039 BindingDB Entry DOI: 10.7270/Q27947QQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50500971![]() (CHEMBL3798983) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KIST) Curated by ChEMBL | Assay Description Inhibition of human C-RAF measured after 40 mins by scintillation counting | Eur J Med Chem 115: 201-16 (2016) Article DOI: 10.1016/j.ejmech.2016.02.039 BindingDB Entry DOI: 10.7270/Q27947QQ | |||||||||||
More data for this Ligand-Target Pair |