BDBM50503860 CHEMBL4475063

SMILES: Cc1c2CCNC(=O)c2ccc1-c1cncc(F)c1

InChI Key: InChIKey=ZFWXPQUBWGSCOX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503860   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 11 (Homo sapiens)	BDBM50503860 (CHEMBL4475063) Show SMILES Cc1c2CCNC(=O)c2ccc1-c1cncc(F)c1 Show InChI InChI=1S/C15H13FN2O/c1-9-12(10-6-11(16)8-17-7-10)2-3-14-13(9)4-5-18-15(14)19/h2-3,6-8H,4-5H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health and Science University Curated by ChEMBL					Assay Description Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...				ACS Med Chem Lett 10: 74-79 (2019) Article DOI: 10.1021/acsmedchemlett.8b00429
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human))	BDBM50503860 (CHEMBL4475063) Show SMILES Cc1c2CCNC(=O)c2ccc1-c1cncc(F)c1 Show InChI InChI=1S/C15H13FN2O/c1-9-12(10-6-11(16)8-17-7-10)2-3-14-13(9)4-5-18-15(14)19/h2-3,6-8H,4-5H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health and Science University Curated by ChEMBL					Assay Description Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...				ACS Med Chem Lett 10: 74-79 (2019) Article DOI: 10.1021/acsmedchemlett.8b00429
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human))	BDBM50503860 (CHEMBL4475063) Show SMILES Cc1c2CCNC(=O)c2ccc1-c1cncc(F)c1 Show InChI InChI=1S/C15H13FN2O/c1-9-12(10-6-11(16)8-17-7-10)2-3-14-13(9)4-5-18-15(14)19/h2-3,6-8H,4-5H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health and Science University Curated by ChEMBL					Assay Description Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...				ACS Med Chem Lett 10: 74-79 (2019) Article DOI: 10.1021/acsmedchemlett.8b00429
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 11 (Homo sapiens)	BDBM50503860 (CHEMBL4475063) Show SMILES Cc1c2CCNC(=O)c2ccc1-c1cncc(F)c1 Show InChI InChI=1S/C15H13FN2O/c1-9-12(10-6-11(16)8-17-7-10)2-3-14-13(9)4-5-18-15(14)19/h2-3,6-8H,4-5H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health and Science University Curated by ChEMBL					Assay Description Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...				ACS Med Chem Lett 10: 74-79 (2019) Article DOI: 10.1021/acsmedchemlett.8b00429
					More data for this Ligand-Target Pair