BDBM50505553 CHEMBL4440858

SMILES: OC[C@@]1(O)CN(C[C@@H]1Oc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cn1

InChI Key: InChIKey=FXSPGILSUUJZOG-RDJZCZTQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50505553 (CHEMBL4440858) Show SMILES OC[C@@]1(O)CN(C[C@@H]1Oc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C17H15ClFN3O5S/c18-12-2-4-16(21-7-12)28(25,26)22-8-15(17(24,9-22)10-23)27-13-3-1-11(6-20)14(19)5-13/h1-5,7,15,23-24H,8-10H2/t15-,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ f...				J Med Chem 62: 9270-9280 (2019) Article DOI: 10.1021/acs.jmedchem.9b01247
					More data for this Ligand-Target Pair