BDBM50505826 CHEMBL4552030

SMILES: CC(=O)Nc1ccc2c(ccnc2c1O)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=UQZPTSATWFGAGJ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505826   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Topoisomerase I/II (Homo sapiens (Human))	BDBM50505826 (CHEMBL4552030) Show SMILES CC(=O)Nc1ccc2c(ccnc2c1O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C18H13F3N2O2/c1-10(24)23-15-7-6-14-13(8-9-22-16(14)17(15)25)11-2-4-12(5-3-11)18(19,20)21/h2-9,25H,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Colorado State University Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...				J Med Chem 62: 10182-10203 (2019) Article DOI: 10.1021/acs.jmedchem.9b01065
					More data for this Ligand-Target Pair