BDBM50505834 CHEMBL4467606

SMILES: CC(=O)Nc1ccc2c(ccnc2c1O)-c1cccc(F)c1

InChI Key: InChIKey=MYPJOJKGCSWSLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Topoisomerase I/II (Homo sapiens (Human))	BDBM50505834 (CHEMBL4467606) Show SMILES CC(=O)Nc1ccc2c(ccnc2c1O)-c1cccc(F)c1 Show InChI InChI=1S/C17H13FN2O2/c1-10(21)20-15-6-5-14-13(7-8-19-16(14)17(15)22)11-3-2-4-12(18)9-11/h2-9,22H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colorado State University Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...				J Med Chem 62: 10182-10203 (2019) Article DOI: 10.1021/acs.jmedchem.9b01065
					More data for this Ligand-Target Pair