Found 4 hits for monomerid = 50505954 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human)) | BDBM50505954
(CHEMBL4562269 | US11168095, Example 97)Show SMILES C[C@H]1CCCOc2cc(F)ccc2C(=O)Nc2cccc(n2)-c2nncn12 |r| Show InChI InChI=1S/C19H18FN5O2/c1-12-4-3-9-27-16-10-13(20)7-8-14(16)19(26)23-17-6-2-5-15(22-17)18-24-21-11-25(12)18/h2,5-8,10-12H,3-4,9H2,1H3,(H,22,23,26)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hr |
J Med Chem 62: 10740-10756 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01206 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human)) | BDBM50505954
(CHEMBL4562269 | US11168095, Example 97)Show SMILES C[C@H]1CCCOc2cc(F)ccc2C(=O)Nc2cccc(n2)-c2nncn12 |r| Show InChI InChI=1S/C19H18FN5O2/c1-12-4-3-9-27-16-10-13(20)7-8-14(16)19(26)23-17-6-2-5-15(22-17)18-24-21-11-25(12)18/h2,5-8,10-12H,3-4,9H2,1H3,(H,22,23,26)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human)) | BDBM50505954
(CHEMBL4562269 | US11168095, Example 97)Show SMILES C[C@H]1CCCOc2cc(F)ccc2C(=O)Nc2cccc(n2)-c2nncn12 |r| Show InChI InChI=1S/C19H18FN5O2/c1-12-4-3-9-27-16-10-13(20)7-8-14(16)19(26)23-17-6-2-5-15(22-17)18-24-21-11-25(12)18/h2,5-8,10-12H,3-4,9H2,1H3,(H,22,23,26)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human)) | BDBM50505954
(CHEMBL4562269 | US11168095, Example 97)Show SMILES C[C@H]1CCCOc2cc(F)ccc2C(=O)Nc2cccc(n2)-c2nncn12 |r| Show InChI InChI=1S/C19H18FN5O2/c1-12-4-3-9-27-16-10-13(20)7-8-14(16)19(26)23-17-6-2-5-15(22-17)18-24-21-11-25(12)18/h2,5-8,10-12H,3-4,9H2,1H3,(H,22,23,26)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-... |
J Med Chem 62: 10740-10756 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01206 |
More data for this
Ligand-Target Pair | |
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