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BDBM50506020 CHEMBL4450702

SMILES: CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(C)cccc1-c1nc2ccccc2[nH]1)c1ccccc1

InChI Key: InChIKey=HZAQQQJYXGYJGM-AREMUKBSSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50506020   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM50506020
PNG
(CHEMBL4450702)
Show SMILES CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(C)cccc1-c1nc2ccccc2[nH]1)c1ccccc1 |r,wD:3.35,(52.74,-6.81,;54.08,-6.04,;55.41,-6.81,;56.75,-6.04,;58.09,-6.8,;59.42,-6.03,;59.42,-4.49,;60.76,-6.8,;60.76,-8.35,;62.09,-9.11,;63.42,-8.34,;63.42,-6.8,;62.09,-6.03,;64.76,-6.03,;64.76,-4.49,;66.09,-6.8,;64.75,-9.11,;66.08,-8.34,;66.84,-6.99,;67.42,-9.11,;67.42,-10.66,;66.08,-11.43,;64.75,-10.66,;63.41,-11.43,;62.01,-10.81,;60.99,-11.95,;59.45,-11.95,;58.67,-13.27,;59.45,-14.61,;60.98,-14.61,;61.75,-13.28,;63.26,-12.96,;56.75,-4.5,;58.08,-3.73,;58.08,-2.19,;56.74,-1.42,;55.4,-2.2,;55.41,-3.74,)|
Show InChI InChI=1S/C32H29N3O3/c1-3-10-26(21-12-5-4-6-13-21)35-31(36)22-17-18-23(25(19-22)32(37)38)29-20(2)11-9-14-24(29)30-33-27-15-7-8-16-28(27)34-30/h4-9,11-19,26H,3,10H2,1-2H3,(H,33,34)(H,35,36)(H,37,38)/t26-/m1/s1
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n/an/an/an/a 0.180n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...

J Med Chem 62: 10456-10465 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01513
More data for this
Ligand-Target Pair