BDBM50506235 CHEMBL4532891

SMILES: ONC(=O)c1ccc(CNC(=O)CNC(=O)CNC(=O)OCc2ccccc2)cc1

InChI Key: InChIKey=QBMSZSBAPJVVGH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50506235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50506235 (CHEMBL4532891) Show SMILES ONC(=O)c1ccc(CNC(=O)CNC(=O)CNC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C20H22N4O6/c25-17(21-10-14-6-8-16(9-7-14)19(27)24-29)11-22-18(26)12-23-20(28)30-13-15-4-2-1-3-5-15/h1-9,29H,10-13H2,(H,21,25)(H,22,26)(H,23,28)(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	335	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition of HDAC6 CD2 domain (unknown origin)				J Med Chem 63: 295-308 (2020) Article DOI: 10.1021/acs.jmedchem.9b01540
					More data for this Ligand-Target Pair