BDBM50506502 CHEMBL4575712

SMILES: NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc2CNC(=O)c2c1

InChI Key: InChIKey=MAHUWMXSXAPPEC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50506502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50506502 (CHEMBL4575712) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc2CNC(=O)c2c1 Show InChI InChI=1S/C19H14N6O5S2/c20-32(28,29)22-8-15-24-25-18(30-15)16(26)19-23-13-4-3-10(6-14(13)31-19)9-1-2-11-7-21-17(27)12(11)5-9/h1-6,22H,7-8H2,(H,21,27)(H2,20,28,29)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50506502 (CHEMBL4575712) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc2CNC(=O)c2c1 Show InChI InChI=1S/C19H14N6O5S2/c20-32(28,29)22-8-15-24-25-18(30-15)16(26)19-23-13-4-3-10(6-14(13)31-19)9-1-2-11-7-21-17(27)12(11)5-9/h1-6,22H,7-8H2,(H,21,27)(H2,20,28,29)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysis				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Hepatic Lipase (HL) (Homo sapiens (Human))	BDBM50506502 (CHEMBL4575712) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc2CNC(=O)c2c1 Show InChI InChI=1S/C19H14N6O5S2/c20-32(28,29)22-8-15-24-25-18(30-15)16(26)19-23-13-4-3-10(6-14(13)31-19)9-1-2-11-7-21-17(27)12(11)5-9/h1-6,22H,7-8H2,(H,21,27)(H2,20,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair