BDBM50506503 CHEMBL4475891

SMILES: NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1

InChI Key: InChIKey=POXKHBMFDRWBCM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50506503   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50506503 (CHEMBL4475891) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1 Show InChI InChI=1S/C16H11FN6O4S2/c17-12-4-2-9(6-19-12)8-1-3-10-11(5-8)28-16(21-10)14(24)15-23-22-13(27-15)7-20-29(18,25)26/h1-6,20H,7H2,(H2,18,25,26)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50506503 (CHEMBL4475891) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1 Show InChI InChI=1S/C16H11FN6O4S2/c17-12-4-2-9(6-19-12)8-1-3-10-11(5-8)28-16(21-10)14(24)15-23-22-13(27-15)7-20-29(18,25)26/h1-6,20H,7H2,(H2,18,25,26)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysis				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Hepatic Lipase (HL) (Homo sapiens (Human))	BDBM50506503 (CHEMBL4475891) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1 Show InChI InChI=1S/C16H11FN6O4S2/c17-12-4-2-9(6-19-12)8-1-3-10-11(5-8)28-16(21-10)14(24)15-23-22-13(27-15)7-20-29(18,25)26/h1-6,20H,7H2,(H2,18,25,26)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair