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SMILES: OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCCCc12)-c1c[nH]c2ncc(F)cc12

InChI Key: InChIKey=RITIYIUBVRXVBU-JFFVOTQRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507238   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polymerase basic protein 2


(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)		BDBM50507238
PNG
(CHEMBL4527175)
Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCCCc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(65.82,-17.63,;67.15,-18.4,;68.49,-17.61,;67.17,-19.94,;68.52,-20.71,;68.53,-22.26,;67.19,-23.04,;65.85,-22.28,;66.62,-20.99,;67.74,-21.89,;65.85,-20.73,;64.51,-19.98,;63.2,-20.76,;63.67,-22.21,;62.65,-23.35,;61.15,-23.05,;60.67,-21.59,;59.17,-21.29,;58.69,-19.82,;59.71,-18.68,;61.22,-18.99,;61.7,-20.44,;63.14,-24.8,;62.24,-26.06,;63.15,-27.31,;64.62,-26.82,;65.96,-27.6,;67.3,-26.82,;67.29,-25.27,;68.63,-24.49,;65.96,-24.5,;64.61,-25.28,)|
Show InChI InChI=1S/C24H26FN5O2/c25-14-9-16-17(11-27-21(16)26-10-14)23-28-18-4-2-1-3-15(18)22(30-23)29-20-13-7-5-12(6-8-13)19(20)24(31)32/h9-13,19-20H,1-8H2,(H,26,27)(H,31,32)(H,28,29,30)/t12?,13?,19-,20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...

Eur J Med Chem 162: 249-265 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.015
More data for this
Ligand-Target Pair