BDBM50507254 CHEMBL4526647

SMILES: ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23

InChI Key: InChIKey=HNNSHRLHFRPHCC-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50507254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50507254 (CHEMBL4526647) Show SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23 Show InChI InChI=1S/C24H23N3O4/c28-21(26-31)12-5-2-6-15-27-23(29)18-11-7-10-17-20(25-16-8-3-1-4-9-16)14-13-19(22(17)18)24(27)30/h1,3-4,7-11,13-14,25,31H,2,5-6,12,15H2,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50507254 (CHEMBL4526647) Show SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23 Show InChI InChI=1S/C24H23N3O4/c28-21(26-31)12-5-2-6-15-27-23(29)18-11-7-10-17-20(25-16-8-3-1-4-9-16)14-13-19(22(17)18)24(27)30/h1,3-4,7-11,13-14,25,31H,2,5-6,12,15H2,(H,26,28)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human HDAC11 (1 to 347 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50507254 (CHEMBL4526647) Show SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23 Show InChI InChI=1S/C24H23N3O4/c28-21(26-31)12-5-2-6-15-27-23(29)18-11-7-10-17-20(25-16-8-3-1-4-9-16)14-13-19(22(17)18)24(27)30/h1,3-4,7-11,13-14,25,31H,2,5-6,12,15H2,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells using RHK-K(Ac)-AMC as...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human))	BDBM50507254 (CHEMBL4526647) Show SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23 Show InChI InChI=1S/C24H23N3O4/c28-21(26-31)12-5-2-6-15-27-23(29)18-11-7-10-17-20(25-16-8-3-1-4-9-16)14-13-19(22(17)18)24(27)30/h1,3-4,7-11,13-14,25,31H,2,5-6,12,15H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50507254 (CHEMBL4526647) Show SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4ccccc4)ccc(C1=O)c23 Show InChI InChI=1S/C24H23N3O4/c28-21(26-31)12-5-2-6-15-27-23(29)18-11-7-10-17-20(25-16-8-3-1-4-9-16)14-13-19(22(17)18)24(27)30/h1,3-4,7-11,13-14,25,31H,2,5-6,12,15H2,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair