BDBM50507256 CHEMBL4476425

SMILES: Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1

InChI Key: InChIKey=ODOKPTUWMSGFKA-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50507256   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50507256 (CHEMBL4476425) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1 Show InChI InChI=1S/C28H30N4O4/c29-22-9-3-4-10-23(22)30-25(33)11-2-1-5-14-32-27(34)20-8-6-7-19-24(31-15-17-36-18-16-31)13-12-21(26(19)20)28(32)35/h3-4,6-10,12-13H,1-2,5,11,14-18,29H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50507256 (CHEMBL4476425) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1 Show InChI InChI=1S/C28H30N4O4/c29-22-9-3-4-10-23(22)30-25(33)11-2-1-5-14-32-27(34)20-8-6-7-19-24(31-15-17-36-18-16-31)13-12-21(26(19)20)28(32)35/h3-4,6-10,12-13H,1-2,5,11,14-18,29H2,(H,30,33)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human HDAC11 (1 to 347 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50507256 (CHEMBL4476425) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1 Show InChI InChI=1S/C28H30N4O4/c29-22-9-3-4-10-23(22)30-25(33)11-2-1-5-14-32-27(34)20-8-6-7-19-24(31-15-17-36-18-16-31)13-12-21(26(19)20)28(32)35/h3-4,6-10,12-13H,1-2,5,11,14-18,29H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human))	BDBM50507256 (CHEMBL4476425) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1 Show InChI InChI=1S/C28H30N4O4/c29-22-9-3-4-10-23(22)30-25(33)11-2-1-5-14-32-27(34)20-8-6-7-19-24(31-15-17-36-18-16-31)13-12-21(26(19)20)28(32)35/h3-4,6-10,12-13H,1-2,5,11,14-18,29H2,(H,30,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50507256 (CHEMBL4476425) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cccc3c(ccc(C1=O)c23)N1CCOCC1 Show InChI InChI=1S/C28H30N4O4/c29-22-9-3-4-10-23(22)30-25(33)11-2-1-5-14-32-27(34)20-8-6-7-19-24(31-15-17-36-18-16-31)13-12-21(26(19)20)28(32)35/h3-4,6-10,12-13H,1-2,5,11,14-18,29H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Deakin University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells using RHK-K(Ac)-AMC as...				Eur J Med Chem 162: 321-333 (2019) Article DOI: 10.1016/j.ejmech.2018.11.020
					More data for this Ligand-Target Pair