Found 2 hits for monomerid = 50508154 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor
(Homo sapiens (Human)) | BDBM50508154
(CHEMBL4582294)Show SMILES CCOc1ccc(cc1CC(O)=O)-c1ccc(CCCc2nn(Cc3ccc(cc3)C(C)(C)C)c(=O)n2-c2ccccc2F)cc1 |(75.79,-18.47,;74.47,-19.26,;73.12,-18.5,;71.8,-19.29,;70.45,-18.53,;69.13,-19.32,;69.15,-20.84,;70.49,-21.61,;71.81,-20.83,;73.15,-21.59,;73.17,-23.13,;71.84,-23.91,;74.51,-23.89,;67.82,-21.63,;67.83,-23.17,;66.51,-23.95,;65.17,-23.19,;63.84,-23.97,;62.5,-23.21,;61.17,-23.99,;59.83,-23.23,;59.35,-21.77,;57.81,-21.77,;56.9,-20.53,;57.68,-19.2,;59.22,-19.22,;60,-17.89,;59.24,-16.55,;57.69,-16.54,;56.92,-17.87,;60.01,-15.22,;61.55,-15.23,;59.25,-13.88,;60.78,-13.88,;57.34,-23.24,;55.88,-23.72,;58.6,-24.13,;58.6,-25.67,;59.94,-26.44,;59.94,-27.99,;58.61,-28.76,;57.27,-27.99,;57.27,-26.44,;55.94,-25.67,;65.15,-21.65,;66.47,-20.87,)| Show InChI InChI=1S/C38H40FN3O4/c1-5-46-34-22-19-29(23-30(34)24-36(43)44)28-17-13-26(14-18-28)9-8-12-35-40-41(25-27-15-20-31(21-16-27)38(2,3)4)37(45)42(35)33-11-7-6-10-32(33)39/h6-7,10-11,13-23H,5,8-9,12,24-25H2,1-4H3,(H,43,44) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Sciences
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human PPARalpha assessed as inhibition of GW7647-induced receptor activation after overnight incubation by cell-ba... |
Bioorg Med Chem Lett 29: 503-508 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.045 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor
(Homo sapiens (Human)) | BDBM50508154
(CHEMBL4582294)Show SMILES CCOc1ccc(cc1CC(O)=O)-c1ccc(CCCc2nn(Cc3ccc(cc3)C(C)(C)C)c(=O)n2-c2ccccc2F)cc1 |(75.79,-18.47,;74.47,-19.26,;73.12,-18.5,;71.8,-19.29,;70.45,-18.53,;69.13,-19.32,;69.15,-20.84,;70.49,-21.61,;71.81,-20.83,;73.15,-21.59,;73.17,-23.13,;71.84,-23.91,;74.51,-23.89,;67.82,-21.63,;67.83,-23.17,;66.51,-23.95,;65.17,-23.19,;63.84,-23.97,;62.5,-23.21,;61.17,-23.99,;59.83,-23.23,;59.35,-21.77,;57.81,-21.77,;56.9,-20.53,;57.68,-19.2,;59.22,-19.22,;60,-17.89,;59.24,-16.55,;57.69,-16.54,;56.92,-17.87,;60.01,-15.22,;61.55,-15.23,;59.25,-13.88,;60.78,-13.88,;57.34,-23.24,;55.88,-23.72,;58.6,-24.13,;58.6,-25.67,;59.94,-26.44,;59.94,-27.99,;58.61,-28.76,;57.27,-27.99,;57.27,-26.44,;55.94,-25.67,;65.15,-21.65,;66.47,-20.87,)| Show InChI InChI=1S/C38H40FN3O4/c1-5-46-34-22-19-29(23-30(34)24-36(43)44)28-17-13-26(14-18-28)9-8-12-35-40-41(25-27-15-20-31(21-16-27)38(2,3)4)37(45)42(35)33-11-7-6-10-32(33)39/h6-7,10-11,13-23H,5,8-9,12,24-25H2,1-4H3,(H,43,44) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Sciences
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human PPARdelta assessed as inhibition of GW0742-induced receptor activation after overnight incubation by cell-ba... |
Bioorg Med Chem Lett 29: 503-508 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.045 |
More data for this Ligand-Target Pair | |