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BDBM50508203 CHEMBL4449996

SMILES: Fc1ccc(cn1)-n1ncc2c(cccc12)C(=O)NCc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=ACXKPCJZZHOFID-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50508203   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50508203
PNG
(CHEMBL4449996)
Show SMILES Fc1ccc(cn1)-n1ncc2c(cccc12)C(=O)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H14F4N4O/c22-19-8-7-15(11-26-19)29-18-6-2-5-16(17(18)12-28-29)20(30)27-10-13-3-1-4-14(9-13)21(23,24)25/h1-9,11-12H,10H2,(H,27,30)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...

Bioorg Med Chem Lett 29: 441-448 (2019)


Article DOI: 10.1016/j.bmcl.2018.12.024
More data for this
Ligand-Target Pair