BDBM50509195 CHEMBL4527166

SMILES: Cc1cccc(C)c1Cn1cc(CCC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)nn1

InChI Key: InChIKey=TZUFWIIGEHKQGE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50509195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50509195 (CHEMBL4527166) Show SMILES Cc1cccc(C)c1Cn1cc(CCC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)nn1 Show InChI InChI=1S/C31H34N10O2S/c1-21-8-7-9-22(2)26(21)20-41-19-25(36-40-41)14-16-28(42)33-27-15-13-23(35-37-27)10-3-4-12-30-38-39-31(44-30)34-29(43)18-24-11-5-6-17-32-24/h5-9,11,13,15,17,19H,3-4,10,12,14,16,18,20H2,1-2H3,(H,33,37,42)(H,34,39,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GLS1 expressed in Escherichia coli strain BL21 (DE3)pLysS pre-incubated for 10 mins before glutamine addition and measured after ...				J Med Chem 62: 9642-9657 (2019) Article DOI: 10.1021/acs.jmedchem.9b01035
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50509195 (CHEMBL4527166) Show SMILES Cc1cccc(C)c1Cn1cc(CCC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)nn1 Show InChI InChI=1S/C31H34N10O2S/c1-21-8-7-9-22(2)26(21)20-41-19-25(36-40-41)14-16-28(42)33-27-15-13-23(35-37-27)10-3-4-12-30-38-39-31(44-30)34-29(43)18-24-11-5-6-17-32-24/h5-9,11,13,15,17,19H,3-4,10,12,14,16,18,20H2,1-2H3,(H,33,37,42)(H,34,39,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of N-[2-[(3',6'-dihydroxy-1-oxo-spiro[isobenzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]ethyl]-N'-[6-[4-[5-[[2-(2-pyridyl)acetyl]amino]...				J Med Chem 62: 9642-9657 (2019) Article DOI: 10.1021/acs.jmedchem.9b01035
					More data for this Ligand-Target Pair