BDBM50509856 CHEMBL4533591

SMILES: Nc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(F)cc1

InChI Key: InChIKey=VZCBGEGPNOADKG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50509856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GRIA1/CACNG2 (Homo sapiens (Human))	BDBM50509856 (CHEMBL4533591) Show SMILES Nc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-5-1-15(2-6-17)19-20(16-3-7-18(24)8-4-16)28-10-9-25-21(22(28)26-19)27-11-13-29-14-12-27/h1-10H,11-14,24H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Rattus norvegicus)	BDBM50509856 (CHEMBL4533591) Show SMILES Nc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-5-1-15(2-6-17)19-20(16-3-7-18(24)8-4-16)28-10-9-25-21(22(28)26-19)27-11-13-29-14-12-27/h1-10H,11-14,24H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of TARPgamma8 in rat hippocampal neurons assessed as inhibition of glutamate-induced current at 10 uM at -60 mV holdin...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599
					More data for this Ligand-Target Pair